People

Uri Laserson

Principal Investigator

I am an Assistant Professor in the Department of Genetics and Genomics Sciences at MSSM. Before that, I spent 4 years in Silicon Valley working on big data and genomics at Cloudera (2012-2016). My graduate training started in the Math department at MIT, but I ended up working on high- throughput immunogenomics in George Church's lab at Harvard (2006-2012). During that time, I co-founded Good Start Genetics, one of the first companies to offer next-generation sequencing in a clinical setting. My thesis research also helped lay some of the groundwork for AbVitro, which was acquired by Juno Therapeutics in 2016.

uri.laserson@mssm.edu

Meimei Shan

Assistant Professor

I finished my graduate training in Zhejiang Medical College of Zhejiang University specializing in molecular biology/immunology. From 1999 to 2005, I worked as a Postdoctoral Fellow in Alfred Prince's lab at the Department of Virology of the New York Blood Center, where I focused on the development of an HCV vaccine in a Chimpanzee model. From 2005 to 2008, I worked as a Senior Research Associate John Moore's lab at the Department of Microbiology and Immunology of Weill Medical College of Cornell University, where I used HIV gp120 as a model antigen to develop an HIV vaccine. In 2010 I joined Andrea Cerutti's lab in the Department of Medicine at MSSM as an Instructor/Assistant Professor where I worked on the regulation of systemic and mucosal immunity. Starting in 2016, I joined the Laserson Lab to work on developing high throughput immunology assays.

meimei.shan@mssm.edu

Tim O'Donnell

PhD Student

I joined the Laserson lab in fall 2017. I'm interested in combining recent advances in machine learning with high throughput experiments to better model and understand immunity. A key project is the development of the MHCflurry software package for peptide/MHC I binding affinity prediction. From 2014-2017, I was a computational biologist in Jeff Hammerbacher's group at Mount Sinai, focusing on analyses of tumor neoantigens using high throughput sequencing datasets. Prior to this, I was an associate research scientist at D. E. Shaw Research, where I studied antibody affinity maturation using molecular dynamics simulations. I've worked as a software engineer at several startups and hold a Bachelor of Science in Mathematics & Computer Science from Brown University.

timothy.odonnell@icahn.mssm.edu

Elliot Merritt

Postdoc

In 2017 I joined the Laserson lab as a postdoc with a focus on high throughput immunological assays. Before joining the lab, I undertook my PhD training in transplantation immunology and mucosal biology at King’s College London (2013–2017). Under the guidance of Alberto Sanchez-Fueyo and Marc Martinez-Llordella, I studied the influence of HCV heterologous immunity on T-cell alloresponses in liver allograft recipients, with a focus on antigen specificity and cross-reactivity. My additional interests included the development of next-generation sequencing-based methylation assays and interrogation of the role of the microbiota in liver transplantation by 16S sequencing. Prior to undertaking my PhD studies, I undertook my Master’s degree studies at King’s College London, which included work on multi-parameter biomarkers of kidney allograft rejection. I have previously worked in development of immunoassays for use in clinical trials while at GlaxoSmithKline, UK (2011–2012). There my work focused primarily on B-cell autoimmunity. My other industry work has included high throughput compound screening assays at Cyprotex, UK.

elliot@lasersonlab.org