Uri Laserson

Principal Investigator

I am an Assistant Professor in the Department of Genetics and Genomics Sciences at MSSM. Before that, I spent 4 years in Silicon Valley working on big data and genomics at Cloudera (2012-2016). My graduate training started in the Math department at MIT, but I ended up working on high- throughput immunogenomics in George Church's lab at Harvard (2006-2012). During that time, I co-founded Good Start Genetics, one of the first companies to offer next-generation sequencing in a clinical setting. My thesis research also helped lay some of the groundwork for AbVitro, which was acquired by Juno Therapeutics in 2016.

Meimei Shan

Assistant Professor

I finished my graduate training in Zhejiang Medical College of Zhejiang University specializing in molecular biology/immunology. From 1999 to 2005, I worked as a Postdoctoral Fellow in Alfred Prince's lab at the Department of Virology of the New York Blood Center, where I focused on the development of an HCV vaccine in a Chimpanzee model. From 2005 to 2008, I worked as a Senior Research Associate John Moore's lab at the Department of Microbiology and Immunology of Weill Medical College of Cornell University, where I used HIV gp120 as a model antigen to develop an HIV vaccine. In 2010 I joined Andrea Cerutti's lab in the Department of Medicine at MSSM as an Instructor/Assistant Professor where I worked on the regulation of systemic and mucosal immunity. Starting in 2016, I joined the Laserson Lab to work on developing high throughput immunology assays.

Tim O'Donnell

PhD Student

I joined the Laserson lab in fall 2017. I'm interested in combining recent advances in machine learning with high throughput experiments to better model and understand immunity. A key project is the development of the MHCflurry software package for peptide/MHC I binding affinity prediction. From 2014-2017, I was a computational biologist in Jeff Hammerbacher's group at Mount Sinai, focusing on analyses of tumor neoantigens using high throughput sequencing datasets. Prior to this, I was an associate research scientist at D. E. Shaw Research, where I studied antibody affinity maturation using molecular dynamics simulations. I've worked as a software engineer at several startups and hold a Bachelor of Science in Mathematics & Computer Science from Brown University.